Article

Single cell kinetic modeling of redox-based drug metabolism in head and neck squamous cell carcinoma

2022-05-18

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) cells are highly heterogeneous in their metabolism and typically experience elevated reactive oxygen species (ROS) levels in the tumor microenvironment. The tumor cells survive under these chronic oxidative conditions by upregulating antioxidant systems compared to healthy cells. Radiation and the majority of chemotherapies used clinically for treatment of HNSCC rely d...

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Literature Corpus work: af17ad9b-f808-5b90-9345-7d24d350c8b7
DOI: 10.1101/2022.05.17.492281

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