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Article

RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease

20 Apr 2021

Abstract excerpt

Abstract Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biological networks that drive cancer progression, although mechanistic insight has been largely limited to the impact of RB loss on cell-cycle regulation. Here, isogenic modeling of RB loss identified disease stage–specific rewiring of E2F1 function, providing the first-in-field mapping of the E2F1 cistrome and...

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PMID: 33879449
DOI: 10.1158/2159-8290.cd-20-1114

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