Article

Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study

2021-04-07

Abstract excerpt

<h4>Aims</h4> Cardiomyocyte-derived induced pluripotent stem cells (iPSCs) may represent a promising therapeutic strategy for severely damaged myocardium. This study aimed to assess the efficacy and safety of clinical grade human iPSC-derived cardiomyocyte (hiPSC-CM) patches and conduct a pre-clinical proof-of-concept analysis. <h4>Methods and results</h4> A clinical grade hiPSC line was established from periphe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95ae0206-93dd-535e-8476-ba6842e6bab8
DOI: 10.1101/2021.04.07.438744

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical StudyDOI 10.1101/2021.04.07.438744Read

Pre-clinical evaluation of the efficacy and safety of human induced pluripotent stem cell-derived cardiomyocyte patchSemantic proximity Read

Transplantation of IPSC-Derived Cardiomyocyte Patches for Ischemic CardiomyopathySemantic proximity Read

Induced Pluripotent Stem Cells Technology and Cardiomyocyte Generation: Progress, Uncertainties and Challenges in the Biological Features and Clinical ApplicationsSemantic proximity Read

Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes.Semantic proximity Read

Human Engineered Heart Tissue Models for Disease Modeling and Drug DiscoverySemantic proximity Read

Modeling heart disease in a dish: from somatic cells to disease-relevant cardiomyocytes.Semantic proximity Read

Effective Cardiac Myocyte Differentiation of Human Induced Pluripotent Stem Cells Requires VEGFSemantic proximity Read

Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult MyocardiumSemantic proximity Read

Human induced pluripotent stem cell-based platform for modeling cardiac ischemia.Semantic proximity Read

Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges.Semantic proximity Read

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.Semantic proximity Read

Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy.Semantic proximity Read