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Article

Human induced pluripotent stem cell-based platform for modeling cardiac ischemia.

Scientific reports - 18 Feb 2021

Häkli Martta, Kreutzer Joose, Mäki Antti-Juhana, Välimäki Hannu, Lappi Henna, Huhtala Heini, Kallio Pasi, Aalto-Setälä Katriina, Pekkanen-Mattila Mari

Abstract excerpt

Ischemic heart disease is a major cause of death worldwide, and the only available therapy to salvage the tissue is reperfusion, which can initially cause further damage. Many therapeutics that have been promising in animal models have failed in human trials. Thus, functional human based cardiac ischemia models are required. In this study, a human induced pluripotent stem cell derived-cardiomyocyte...

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Identifiers

PMID: 33603154
DOI: 10.1038/s41598-021-83740-w
PMCID: PMC7893031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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