Article

Urinary proteins from Sickle Cell patients induce inflammation and kidney injury via the TGFβ-p53 axis in a podocyte cell culture model

2025-08-09

Abstract excerpt

<h4>Background</h4> Sickle cell disease (SCD) is an inherited blood disorder affecting the oxygen-carrying hemoglobin in red blood cells making them deform into a sickle shape. Hemolysis and vaso-occlusion associated with this process can lead to complications in many organs and frequently to renal complications. Numerous factors are considered to contribute towards the development of proteinuria (PU) in SCD incl...

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Literature Corpus work: 95a3955a-0f4e-57ba-8572-8fc6ef50fa71
DOI: 10.1101/2025.08.08.669286

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