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Article

Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua

27 Jun 2024

Abstract excerpt

The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify mechanisms of innate immune restriction exclusively in the fetal compartment of the placenta. ZIKV principally infected mononuclear trophoblasts in the junctional zone, which was limited by mitochondrial antiviral-signaling protein (MAVS)...

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PMID: 39042188
DOI: 10.1084/jem.20240694

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