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Zika virus infection in immunocompetent pregnant mice causes fetal damage and placental pathology in the absence of fetal infection

10 Apr 2018

Abstract excerpt

Zika virus (ZIKV) infection during human pregnancy may cause diverse and serious congenital defects in the developing fetus. Previous efforts to generate animal models of human ZIKV infection and clinical symptoms often involved manipulating mice to impair their Type I interferon (IFN) signaling, thereby allowing enhanced infection and vertical transmission of virus to the embryo. Here, we show that even pregnant...

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PMID: 29634758
DOI: 10.1371/journal.ppat.1006994

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