Article

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes

2022-10-18

Abstract excerpt

<title>Abstract</title> <p>Association of single nucleotide polymorphisms in the IL-23 receptor with the several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapies directed against the cytokine have been licenced and a new class of small peptide antagonists of the receptor have entered clinical trials. T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9525f856-7639-5fff-a9a2-cb1279169100
DOI: 10.21203/rs.3.rs-2118755/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probesDOI 10.21203/rs.3.rs-2118755/v1Read

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.Semantic proximity Read

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.Semantic proximity Read

Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodiesSemantic proximity Read

Flexible regions govern promiscuous binding of IL ‐24 to receptors IL ‐20R1 and IL ‐22R1Semantic proximity Read

Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen-activated leukocytes.Semantic proximity Read

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses.Semantic proximity Read

The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species.Semantic proximity Read

The role of CD23 in IgE dependent signaling: implications from pharmacogenetics.Semantic proximity Read

A novel class of anti-IL-12p40 antibodies: potent neutralization via inhibition of IL-12-IL-12Rβ2 and IL-23-IL-23R.Semantic proximity Read

Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23Semantic proximity Read

CD23 interacts with a new functional extracytoplasmic domain involving N-linked oligosaccharides on CD21.Semantic proximity Read

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonismSemantic proximity Read