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Article

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.

Nature communications - 19 May 2023

Lay Charles S, Isidro-Llobet Albert, Kilpatrick Laura E, Craggs Peter D, Hill Stephen J

Abstract excerpt

Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapies directed against the cytokine have been licenced and a class of small peptide antagonists of the receptor have entered clinical trials. These peptide antagonists may offer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37208328
DOI: 10.1038/s41467-023-38541-2
PMCID: PMC10199020

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