Article

Crystal structure of an AT-hook motif bound to DNA and inhibition by antikinetoplastid minor groove binders

2024-09-24

Abstract excerpt

<title>Abstract</title> <p>High mobility group (HMG) proteins are intrinsically disordered nuclear non-histone chromosomal proteins that play an essential role in many biological processes by regulating the expression of numerous genes in eukaryote cells. HMGA proteins contain three DNA binding motifs, the “AT-hooks”, that bind preferentially to AT-rich sequences in the minor groove of B-form DNA. Understanding t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95033738-c5cf-5921-982b-d52717d70e24
DOI: 10.21203/rs.3.rs-4963039/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of an AT-hook motif bound to DNA and inhibition by antikinetoplastid minor groove bindersDOI 10.21203/rs.3.rs-4963039/v1Read

Noncovalent interactions with DNA: an overview.Semantic proximity Read

DNA aptamers for the recognition of HMGB1 from <i>Plasmodium falciparum</i>Semantic proximity Read

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics.Semantic proximity Read

Non-covalent ligand/DNA interactions: minor groove binding agents.Semantic proximity Read

PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activitySemantic proximity Read

Strong binding of naphthyridine derivatives to a guanine base in DNA duplexes containing an AP site.Semantic proximity Read

Major groove recognition by three-stranded beta-sheets: affinity determinants and conserved structural features.Semantic proximity Read

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.Semantic proximity Read

Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.Semantic proximity Read

Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation.Semantic proximity Read

Sequence-specific recognition of DNA by hydrophobic, alanine-rich mutants of the basic region/leucine zipper motif investigated by fluorescence anisotropy.Semantic proximity Read

HIV chromatin is a preferred target for drugs that bind in the DNA minor grooveSemantic proximity Read