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Article

Major groove recognition by three-stranded beta-sheets: affinity determinants and conserved structural features.

Journal of molecular biology - 21 Jul 2000

Connolly K M, Ilangovan U, Wojciak J M, Iwahara M, Clubb R T

Abstract excerpt

We present the results of a rational mutagenesis and binding-affinity study of the three-stranded beta-sheet-DNA interface in the complex formed by the amino-terminal DNA-binding domain of the Tn916 integrase protein and its cognate binding site. The relative importance of interfacial contacts present in its NMR-derived solution structure have been tested through mutagenesis, fluorescence anisotropy, and...

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Identifiers

PMID: 10891272
DOI: 10.1006/jmbi.2000.3888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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