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Article

PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activity

2 Jul 2010

Abstract excerpt

BACKGROUND AND PURPOSE: PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In this study we have characterized the interactions of PM01183 with selected DNA molecules of defined sequence and its in vitro and in vivo cytotoxicity. EXPERIMENTAL APPROACH: DNA binding characteristics of PM01183 were studied using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20977459
DOI: 10.1111/j.1476-5381.2010.00945.x

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