Article

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove

2019-04-26

Abstract excerpt

<h4>ABSTRACT</h4> The HIV genome is rich in A but not G or U and deficient in C. This nucleotide bias controls HIV phenotype by determining the highly unusual composition of all majors HIV proteins. Since drugs that bind in the DNA minor groove disrupt nucleosomes on sequences that contain closely spaced oligo-A tracts which are prevalent in HIV DNA because of this bias, it was of interest to determine if these d...

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Literature Corpus work: 14939a55-dfdd-5661-affb-dfabc1547f64
DOI: 10.1101/618090

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