Article
Non-covalent ligand/DNA interactions: minor groove binding agents.
Mutation research - 1 Oct 2007
Nelson Stephanie M, Ferguson Lynnette R, Denny William A
Abstract excerpt
An understanding of the mechanism by which minor groove binding agents interact with DNA has led to the design of agents that can reversibly bind with high selectivity to extended DNA target sequences. Simple compounds, such as the polypyrroles and the bis-benzimidazoles, have been used as carriers for alkylating agents effectively directing alkylation to specific DNA sequences. The spectrum of DNA alkylation and...
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