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Single-cell atlas of patient-derived cervical organoids uncovers epithelial immune heterogeneity and intercellular crosstalk during Chlamydia infection

2025-04-18

Abstract excerpt

The uterine cervix is a critical mucosal interface that balances immune defense and reproductive function, yet how its distinct epithelial compartments coordinate responses to infection remains unclear. Here, we integrate patient-derived 3D cervical organoids, single-cell transcriptomics and native tissue analysis to construct a high-resolution atlas of epithelial cell diversity and immune dynamics during Chlamyd...

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Literature Corpus work
94e9ad48-9604-587e-9d81-48750954d533
DOI
10.1101/2025.04.13.648603
Open publication

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Single-cell atlas of patient-derived cervical organoids uncovers epithelial immune heterogeneity and intercellular crosstalk during Chlamydia infectionDOI 10.1101/2025.04.13.648603
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