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Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

29 May 2024

Abstract excerpt

Modulation of the cervix by steroid hormones and commensal microbiome play a central role in the health of the female reproductive tract. Here we describe organ-on-a-chip (Organ Chip) models that recreate the human cervical epithelial-stromal interface with a functional epithelial barrier and production of mucus with biochemical and hormone-responsive properties similar to living cervix. When Cervix Chips are...

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PMID: 38811586
DOI: 10.1038/s41467-024-48910-0

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