Article

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

2023-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Modulation of mucus production by the human endo– and ecto-cervical epithelium by steroid hormones and associated interactions with commensal microbiome play a central role in the physiology and pathophysiology of the female reproductive tract. However, most of our knowledge about these interactions is based on results from animal studies or in vitro models that fail to faithfully mimic the muc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2c079c9-689e-529c-ba17-2e2adeaa015b
DOI: 10.1101/2023.02.22.529436

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chipsDOI 10.1101/2023.02.22.529436Read

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chipsSemantic proximity Read

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive HealthSemantic proximity Read

Replicating Host–Microbiome Interactions: Harnessing Organ-on-a-Chip and Organoid Technologies to Model Vaginal and Lung PhysiologySemantic proximity Read

Single-cell atlas of patient-derived cervical organoids uncovers epithelial immune heterogeneity and intercellular crosstalk during Chlamydia infectionSemantic proximity Read

Transcriptional profiling of mucus production and modification in rhesus macaque endocervical cells under hormonal regulationSemantic proximity Read

Microbiome-metabolome analysis reveals cervical lesion alterationsSemantic proximity Read

Three-dimensional models of the cervicovaginal epithelia to study host-microbiome interactions and sexually transmitted infectionsSemantic proximity Read

Three-dimensional models of the cervicovaginal epithelia to study host–microbiome interactions and sexually transmitted infectionsSemantic proximity Read

Differential Host Gene Expression Associated with Non-Lactobacillus-dominant Vaginal Microbiomes During PregnancySemantic proximity Read

Generation of Human Endometrial Assembloids with a Luminal Epithelium using Air–Liquid Interface Culture MethodsSemantic proximity Read

Distinct cervical microbiome and metabolite profiles before and after menopause: implications for cervical cancer progressionSemantic proximity Read

Human Three-Dimensional Endometrial Epithelial Cell Model To Study Host Interactions with Vaginal Bacteria and Neisseria gonorrhoeae.Semantic proximity Read