Article

Resonant fluctuations of selection pressure exponentially accelerate fitness valley crossing

2022-01-04

Abstract excerpt

Two functional protein sequences can sometimes be separated by a fitness valley - a series of low or non-functional intermediate mutations that must be traversed to reach a more optimal or refined function. Time-varying selection pressure modulates evolutionary sampling of such valleys. Yet, how the amplitude and frequency of fluctuating selection influence the rate of protein evolution is poorly understood. Here,...

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Identifiers and source

Literature Corpus work: 94c96212-b123-5e35-93e6-a6f8ea2f5145
DOI: 10.1101/2022.01.03.474754

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