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Article

The rate of fitness-valley crossing in sexual populations.

Genetics - 1 Dec 2010

Weissman Daniel B, Feldman Marcus W, Fisher Daniel S

Abstract excerpt

Biological traits result in part from interactions between different genetic loci. This can lead to sign epistasis, in which a beneficial adaptation involves a combination of individually deleterious or neutral mutations; in this case, a population must cross a "fitness valley" to adapt. Recombination can assist this process by combining mutations from different individuals or retard it by breaking up the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genetics, Population

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Share to Recombination, Genetic

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Source

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Identifiers

PMID: 20923976
DOI: 10.1534/genetics.110.123240
PMCID: PMC2998319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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