Article

Full-length mRNA sequencing uncovers a widespread coupling between transcription and mRNA processing

2017-07-18

Abstract excerpt

<h4>ABSTRACT</h4> The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the interdependence of transcription, splicing and polyadenylation events on single mRNA molecules by full-length mRNA sequencing. In MCF-7 breast cancer cells, we found 2,700 genes with interdependent alternative transcription, spli...

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Literature Corpus work: 94c049e8-9303-5356-876f-966582cc8ec9
DOI: 10.1101/165092

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