Article

GPU-Accelerated Optimization Investigates Synaptic Reorganization Underlying Pathological Beta Oscillations in a Basal Ganglia Network Model

2026-04-21

Abstract excerpt

<h4>Objective</h4> Pathological beta-band oscillations (13 to 30 Hz) in the subthalamic nucleus (STN) are a hallmark of Parkinson’s disease and a primary target for deep brain stimulation therapy, yet the specific pattern of synaptic reorganization that drives their emergence remains incompletely understood. We developed a GPU-accelerated computational framework to systematically investigate combinations of synap...

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Literature Corpus work: 94adc39f-43e0-5028-8cc1-44f6092df497
DOI: 10.64898/2026.04.16.718939

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