Article

Fast and Easy Whole-Brain Network Model Parameter Estimation with Automatic Differentiation

2025-11-18

Abstract excerpt

Personalized brain modeling at clinically relevant scales requires integrating biophysical models with empirical neuroimaging data, yet high-dimensional parameter estimation in whole-brain network models remains computationally prohibitive. We present TVB-Optim, an open-source Python library providing a general and extensible framework for gradient-based optimization of brain network models build on JAX. Leveragin...

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Literature Corpus work: 5dd2703b-defa-5990-b842-af330cf1a6c3
DOI: 10.1101/2025.11.18.689003

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