Article

Uncovering network mechanism underlying thalamic deep brain stimulation

2023-12-10

Abstract excerpt

Thalamic ventral intermediate nucleus (Vim) is the primary surgical target of deep brain stimulation (DBS) for reducing symptoms of essential tremor. High-frequency Vim-DBS (≥100Hz) has been clinically effective, generating two experimentally-observed features in Vim spiking activity: 1) a large transient excitatory response (lasting <1s), followed by 2) a suppressed steady-state consisting of oscillations. Yet, m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97ff512f-36f4-5a06-8d46-128e4e0191e4
DOI: 10.1101/2023.12.09.570924

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uncovering network mechanism underlying thalamic deep brain stimulationDOI 10.1101/2023.12.09.570924Read

Modelling Instantaneous Firing Rate of DBS Target Neuronal Ensembles in Basal Ganglia and ThalamusSemantic proximity Read

Biophysical modeling of VIM to assess contributions of oscillatory activity to essential tremorSemantic proximity Read

Modeling mechanisms of tremor reduction for essential tremor using symmetric biphasic DBSSemantic proximity Read

Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremorSemantic proximity Read

Cortico-thalamic excitatory-inhibitory dynamics generates <i>α</i> -wave transient patterns encoding anesthetic brain statesSemantic proximity Read

Modeling the role of the thalamus in resting-state functional connectivity: nature or structureSemantic proximity Read

Rhythmic modulation of subthalamo-pallidal interactions depends on synaptic rewiring through inhibitory plasticitySemantic proximity Read

Thalamic control of sensory enhancement and sleep spindle properties in a biophysical model of thalamoreticular microcircuitrySemantic proximity Read

Robust Adaptive Deep Brain Stimulation Control of Non-Stationary Cortex-Basal Ganglia-Thalamus Network Models in Parkinson’s DiseaseSemantic proximity Read

A multi-frequency whole-brain neural mass model with homeostatic feedback inhibitionSemantic proximity Read

Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic modelSemantic proximity Read

Adaptive Parameter Modulation of Deep Brain Stimulation in a Computational Model of Basal Ganglia-thalamic NetworkSemantic proximity Read