Article

Sequence constraints predispose Class D GPCRs to follow an atypical activation mechanism

2026-01-14

Abstract excerpt

The biophysical principles underlying distinct conformational changes in proteins with similar topologies remain poorly understood. Class D G Protein-Coupled Receptors (GPCRs), fungal pheromone-sensing receptors essential for mating and survival, exhibit an atypical activation mechanism compared to other GPCR classes. Unlike Class A GPCRs, which activate through outward movement of TM6, Class D receptors undergo a...

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Literature Corpus work: 94a62df8-e2b8-56b7-bbdf-3a750d3650f3
DOI: 10.64898/2026.01.14.699465

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