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Article

Allosteric pathways of SARS and SARS-CoV-2 spike protein identified by neural relational inference.

Proteins - 1 Jul 2024

Hu Yao, Li Mingwei, Wang Qian

Abstract excerpt

The receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein must undergo a crucial conformational transition to invade human cells. It is intriguing that this transition is accompanied by a synchronized movement of the entire spike protein. Therefore, it is possible to design allosteric regulators targeting non-RBD but hindering the conformational transition of...

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Identifiers

PMID: 38459426
DOI: 10.1002/prot.26678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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