Article

Familial risk and illness burden jointly shape prefrontal hypoactivation in depression: An fNIRS study

2026-01-25

Abstract excerpt

<title>Abstract</title> <p>Prefrontal dysfunction is a well-documented deficit in major depressive disorder (MDD), yet it remains unclear whether this represents a genetic endophenotype or a persistent "scar" of the illness. This study aimed to disentangle familial risk from disease chronicity by simultaneously examining remitted MDD (rMDD) patients, unaffected high-risk (HR) individuals, and healthy controls (HC...

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Literature Corpus work: 94670ded-68b7-5ea7-a60e-f149f8f9a053
DOI: 10.21203/rs.3.rs-8537776/v1

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