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Article

Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy.

Progress in biophysics and molecular biology - 1 Nov 2017

Zile Melanie A, Trayanova Natalia A

Abstract excerpt

Patients with hypertrophic cardiomyopathy (HCM), a disease associated with sarcomeric protein mutations, often suffer from sudden cardiac death (SCD) resulting from arrhythmia. In order to advance SCD prevention strategies, our understanding of how sarcomeric mutations in HCM patients contribute to enhanced arrhythmogenesis needs to be improved. Early afterdepolarizations (EADs) are an important mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28648627
DOI: 10.1016/j.pbiomolbio.2017.06.015
PMCID: PMC5716843

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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