Article

Targeting SUV4-20H epigenetic enzymes as therapeutic strategy for enhancing topoisomerase II poisoning in prostate cancer

2025-03-14

Abstract excerpt

<h4>SUMMARY</h4> DNA topoisomerase II (TOP2) plays a crucial role in DNA-associated processes by inducing transient DNA double-strand breaks, making it an important target for DNA-damage stabilizing agents. Commonly used in cancer therapy, these agents are designed to interfere with TOP2 cleavage complexes on chromatin. However, the epigenetic pathways influencing their effectiveness and the resultant cellular re...

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Literature Corpus work: 94047c33-274c-5855-b243-d6cedc272cd0
DOI: 10.1101/2025.03.11.642623

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