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Article

Effective targeting of RNA polymerase I in treatment‐resistant prostate cancer

16 Sept 2019

Abstract excerpt

Abstract Background Advanced prostate cancers depend on protein synthesis for continued survival and accelerated rates of metabolism for growth. RNA polymerase I (Pol I) is the enzyme responsible for ribosomal RNA (rRNA) transcription and a rate‐limiting step for ribosome biogenesis. We have shown using a specific and sensitive RNA probe for the 45S rRNA precursor that rRNA synthesis is increased in prostate...

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PMID: 31524299
DOI: 10.1002/pros.23909

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