Article

Signatures of mast cell activation are associated with severe COVID-19

2021-06-01

Abstract excerpt

Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in severely ill patients and the pathophysiology of disease is thought to be immune-mediated. Mast cells (MCs) are polyfunctional immune cells present in the airways, where they respond to certain viruses and allergens, often promoting inflammation. We observed widespread degranulation of MCs during acute and unresolved airway inflammation in S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93f170e9-853c-555d-ad6e-fcb3cad0e463
DOI: 10.1101/2021.05.31.21255594

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Signatures of mast cell activation are associated with severe COVID-19DOI 10.1101/2021.05.31.21255594Read

SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung InjurySemantic proximity Read

Absence of severe COVID-19 in patients with clonal mast cells activation disorders: effective anti-SARS-CoV-2 immune responseSemantic proximity Read

Mast cell activation signature as a potential biomarker in COVID-19Semantic proximity Read

Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program.Semantic proximity Read

Mast cell populations shift and adapt transcription profiles during the resolution of allergic airway inflammationSemantic proximity Read

Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signalingSemantic proximity Read

Mast cells, their subtypes, and relation to asthma phenotypes.Semantic proximity Read

Analysis of human lung mast cells by single cell RNA sequencingSemantic proximity Read

Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammationSemantic proximity Read

IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.Semantic proximity Read

Effects of C3aR activated mast cells in eosinophilic esophagitisSemantic proximity Read