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Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation

18 Aug 2020

Abstract excerpt

Murine mast cells (MCs) contain two lineages: inducible bone marrow-derived mucosal MCs (MMCs) and constitutive embryonic-derived connective tissue MCs (CTMCs). Here, we use RNA sequencing, flow cytometry, and genetic deletion in two allergic lung inflammation models to define these two lineages. We found that inducible MCs, marked by β7 integrin expression, are highly distinct from airway CTMCs at rest and...

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PMID: 32946563
DOI: 10.1084/jem.20200321

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