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Article

IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2013

Jung Mi-Yeon, Smrž Daniel, Desai Avanti, Bandara Geethani, Ito Tomonobu, Iwaki Shoko, Kang Jeong-Han, Andrade Marcus V, Hilderbrand Susana C, Brown Jared M, Beaven Michael A, Metcalfe Dean D, Gilfillan Alasdair M

Abstract excerpt

IL-33 is elevated in afflicted tissues of patients with mast cell (MC)-dependent chronic allergic diseases. Based on its acute effects on mouse MCs, IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. However, the manifestations of prolonged IL-33 exposure on human MC function, which best reflect the conditions associated with chronic allergic disease, are unknown. In...

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Identifiers

PMID: 23248261
DOI: 10.4049/jimmunol.1201576
PMCID: PMC3538948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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