Article
Tension monitoring during epithelial-to-mesenchymal transition links the switch of phenotype to expression of moesin and cadherins in NMuMG cells.
PloS one - 1 Jan 2013
Schneider David, Baronsky Thilo, Pietuch Anna, Rother Jan, Oelkers Marieelen, Fichtner Dagmar, Wedlich Doris, Janshoff Andreas
Abstract excerpt
Structural alterations during epithelial-to-mesenchymal transition (EMT) pose a substantial challenge to the mechanical response of cells and are supposed to be key parameters for an increased malignancy during metastasis. Herein, we report that during EMT, apical tension of the epithelial cell line NMuMG is controlled by cell-cell contacts and the architecture of the underlying actin structures reflecting the...
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