Article

Lipid Disbalance Affects Neuronal Dendrite Growth and Maintenance in a Human Ceramide Synthase Disease Model

2024-10-31

Abstract excerpt

<h4>Summary</h4> The brain is susceptible to disturbances in lipid metabolism. Among the rare, genetically-linked epilepsies Progressive Myoclonic Epilepsy Type 8 (PME8), associated with the loss of Ceramide Synthase (CerS) activity, causes epileptic symptoms accompanied by neurodegenerative traits. We show that expression of a disease-causing c erS allele in Drosophila sensory neurons yielded developmental and...

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Literature Corpus work: 93cf3361-a07d-5bad-b9a0-8e584b1e11a4
DOI: 10.1101/2024.10.31.621235

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