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Lipid metabolic perturbation is an early-onset phenotype in adult <i>spin</i> mutants: a <i>Drosophila</i> model for lysosomal storage disorders

2016-09-16

Abstract excerpt

Intracellular accumulation of lipids and swollen dysfunctional lysosomes are linked to several neurodegenerative diseases including lysosomal storage disorders (LSD). A detailed characterization of lipid metabolic changes in relation to the onset and progression of neurodegeneration is currently missing. In this study, we systematically analyzed lipid perturbations in spinster (spin) mutants, a Drosophila model...

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Literature Corpus work
298fb8ab-5c71-589a-bc49-5f85a8d59b35
DOI
10.1101/075556
Open publication

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Lipid metabolic perturbation is an early-onset phenotype in adult <i>spin</i> mutants: a <i>Drosophila</i> model for lysosomal storage disordersDOI 10.1101/075556
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