Article

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

2022-10-21

Abstract excerpt

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular alterations are incompletely understood. To delineate the cellular and molecular basis for DN initiation, we performed single-cell and bulk RNA sequencing of renal cells from type 2 diabet...

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Literature Corpus work: 39d8c706-8a04-5e6c-8f82-b12945f816a2
DOI: 10.1101/2022.10.19.512894

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