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Article

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

10 Jan 2023

Abstract excerpt

BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular alterations are incompletely understood. METHODS: To delineate the cellular and molecular basis for DN initiation, we performed single-cell and bulk RNA sequencing of renal...

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Share to Chronic Kidney Disease and Diabetes
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PMID: 36627643
DOI: 10.1186/s13073-022-01145-4

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