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A Nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosing

2023-09-10

Abstract excerpt

<h4>Rationale</h4> Standardized dosing of anti-tubercular (TB) drugs leads to variable plasma drug levels, which are associated with adverse drug reactions, delayed treatment response, and relapse. Mutations in genes affecting drug metabolism explain considerable interindividual pharmacokinetic variability; however, pharmacogenomic (PGx) assays that predict metabolism of anti-TB drugs have been lacking. <h4>Object...

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Literature Corpus work
92cc1e22-50a2-57c0-a0eb-05c502be0c1c
DOI
10.1101/2023.09.08.23295248
Open publication

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A Nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosingDOI 10.1101/2023.09.08.23295248
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