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Article

DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.

G3 (Bethesda, Md.) - 27 Apr 2015

Fotopoulos Pauline, Kim Jeongho, Hyun Moonjung, Qamari Waiss, Lee Inhwan, You Young-Jai

Abstract excerpt

mua-3 is a Caenorhabditis elegans homolog of the mammalian fibrillin1, a monogenic cause of Marfan syndrome. We identified a new mutation of mua-3 that carries an in-frame deletion of 131 amino acids in the extracellular domain, which allows the mutants to survive in a temperature-dependent manner; at the permissive temperature, the mutants grow normally without obvious phenotypes, but at the nonpermissive...

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Identifiers

PMID: 25917920
DOI: 10.1534/g3.115.018465
PMCID: PMC4502371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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