Article

UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease

2022-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Despite current improvements in systemic cancer treatment, brain metastases (BM) remain incurable, and there is an unmet clinical need for effective targeted therapies. Here, we sought common molecular events in brain metastatic disease. RNA sequencing of thirty human BM identified the upregulation of UBE2C , a gene that ensures the correct transition from metaphase to anaphase, across differen...

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Literature Corpus work: 9381212c-d62c-5990-a1ce-0921a067303a
DOI: 10.1101/2022.10.04.510674

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