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Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH

9 Mar 2024

Abstract excerpt

Abstract Aim To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH). Methods We profiled single-LSEC from livers of control and MCD-fed mice. The functions of C-Kit + -LSECs were determined using coculture and bone marrow transplantation (BMT) methods. Results Three special clusters of single-LSEC were differentiated. C-Kit + -LSECs of cluster 0, Msr1 + -LSECs...

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PMID: 38461242
DOI: 10.1186/s13578-024-01215-7

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