Article

Targeting CXCR4-expressing TAMs in muscle-invasive bladder cancer to enhance tumor control after immunotherapy

2025-03-25

Abstract excerpt

Bladder cancer (BC) is a prevalent malignancy with poor prognosis in advanced stages. While immune checkpoint blockade has revolutionized immunotherapy, its efficacy remains limited for most advanced BC patients. The detailed characterization of BC’s tumor microenvironment (TME) is a prerequisite to understand these mechanisms of resistance and to develop new therapeutic strategies. In this study, we used a geneti...

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Literature Corpus work: 3bce9f08-3cd4-5017-be64-0b6fe553d49a
DOI: 10.1101/2025.03.21.644543

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