Article

Doxorubicin Drives Chemoresistance in Osteosarcoma by Inducing Adaptive Plasticity and IL-1β/COX-2-mediated Inflammation

2026-08-07

Abstract excerpt

<title>Abstract</title> <p>Osteosarcoma is the most frequent bone malignancy in children and adolescents. Unfortunately, despite advances in treatment, chemoresistance and tumour recurrence remain major challenging obstacles. Increasing evidence suggests that surviving malignant cells can undergo adaptive reprogramming following chemotherapy, attaining cancer stem cell (CSC)-associated characteristics and other c...

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Literature Corpus work: 934b9033-af0a-5b92-809e-2f8e06724494
DOI: 10.21203/rs.3.rs-10122129/v1

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