Article

Identification of TIMP2 and RAX as key regulators in chemosensitive osteosarcoma

2020-07-29

Abstract excerpt

<h4>Background: </h4> This study is trying to investigate the regulation mechanism of chemosensitive osteosarcoma. mRNA and miRNA profiles were explored between chemosensitive and chemoresistant osteosarcoma patients based on GSE39058 dataset. IPA was used for pathway and function enrichment. Another dataset GSE21257 with clinical characteristics was used for survival analysis, and 68 new enrolled osteosarcoma pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f054075-2d10-5da4-8d24-78e386dd8dfd
DOI: 10.21203/rs.3.rs-47947/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of TIMP2 and RAX as key regulators in chemosensitive osteosarcomaDOI 10.21203/rs.3.rs-47947/v1Read

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and ChemoresistanceSemantic proximity Read

Exploration of Various Roles of Hypoxia Genes in OsteosarcomaSemantic proximity Read

The molecular mechanisms of chemoresistance in cancersSemantic proximity Read

Molecular characterization of metastatic osteosarcoma: Differentially expressed genes, transcription factors and microRNAsSemantic proximity Read

Identification of a Programmed Cell Death-related Signature for Prediction of OsteosarcomaSemantic proximity Read

A tumor microenvironment-based prognostic index for osteosarcomaSemantic proximity Read

Development and Validation of a Robust Apoptosis-related Prognostic Classifier in Patients With OsteosarcomaSemantic proximity Read

Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experimentsSemantic proximity Read

TGF-β signaling pathway-based model to predict prognosis and immunity in osteosarcoma patientsSemantic proximity Read

Identification of key biomarkers and functional pathways in osteosarcomas with lung metastasis: Evidence from bioinformatics analysisSemantic proximity Read

Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential InhibitorsSemantic proximity Read

Molecular Signaling Pathways as Potential Therapeutic Targets in OsteosarcomaSemantic proximity Read