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Article

Targeting the mTOR Pathway in Leukemia

28 Mar 2016

Abstract excerpt

Optimal function of multiple intracellular signaling pathways is essential for normal regulation of cellular transcription, translation, growth, proliferation, and survival. Dysregulation or aberrant activation of such cascades can lead to inappropriate cell survival and abnormal cell proliferation in leukemia. Successful treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors targeting the...

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PMID: 27018341
DOI: 10.1002/jcb.25559

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