Elucidating ferroptosis mechanisms in heart failure through transcriptomics, single-cell sequencing, and experimental validation

Abstract excerpt

BACKGROUND: The mechanisms underlying ferroptosis in heart failure (HF) remain incompletely understood. METHODS: This study analyzed the heart failure dataset from the Gene Expression Omnibus to identify differentially expressed ferroptosis-related genes (DFRGs). Key DFRGs were selected using LASSO regression and SVM-RFE machine learning techniques. Their diagnostic accuracy was evaluated via ROC curve analysis....

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