Article

Parl Deficiency in Mouse Causes Coenzyme Q Depletion, Complex III Defects, and Leigh-like Syndrome

2018-07-13

Abstract excerpt

<h4>ABSTRACT</h4> The mitochondrial intramembrane rhomboid protease Parl has been implicated in diverse functions in vitro , but its physiological role in vivo remains unclear. Here we show that Parl ablation in mouse causes a striking necrotizing encephalomyelopathy similar to Leigh syndrome, a mitochondrial disease characterized by disrupted energy production. Mice with conditional Parl deficiency in the ner...

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Identifiers and source

Literature Corpus work: 93448340-36c6-5be7-991e-286091aece98
DOI: 10.1101/368654

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