Article

<i>Yap</i> haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy

2020-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected temporal dynamic of gene compensation. At post-natal stages, Taz upregulation occurs, leading to a gain...

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Literature Corpus work: 933c032f-1069-571a-b51f-b4aa416bb658
DOI: 10.1101/2020.02.18.953943

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