Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina

29 May 2021

Abstract excerpt

Although adeno-associated viral (AAV) vector-mediated retinal gene therapies have demonstrated efficacy, the mechanisms underlying dose-dependent retinal inflammation remain poorly understood. Here, we present a quantitative analysis of cellular immune response to subretinal AAV gene therapy in mice using multicolor flow cytometry with a panel of key immune cell markers. A significant increase in CD45 + retinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Retinal and Optic Conditions
Share to Retinal Development and Disorders
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34485594
DOI: 10.1016/j.omtm.2021.05.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retinaPMID 34485594Read ↗

Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition MechanismSemantic proximity Read ↗

Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primatesSemantic proximity Read ↗

Host immune responses after suprachoroidal delivery of AAV8 in nonhuman primate eyesSemantic proximity Read ↗

Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene TherapySemantic proximity Read ↗

AAV-delivered CRISPR-Cas9 elicits persistent retinal immune responses compared with transient responses to RNPSemantic proximity Read ↗

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degenerationSemantic proximity Read ↗

Preclinical Safety Evaluation of AAV5-hRORA Gene Therapy for Geographic Atrophy and ABCA4-Related RetinopathiesSemantic proximity Read ↗

Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in RatsSemantic proximity Read ↗

Ocular Inflammatory Response to Intravitreal Injection of Adeno-Associated Virus Vector: Relative Contribution of Genome and CapsidSemantic proximity Read ↗

AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular DegenerationSemantic proximity Read ↗

Immunology of AAV-Mediated Gene Transfer in the EyeSemantic proximity Read ↗

Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profileSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.