Article

Burst-like Secretion of Platelet Dense Granules Promotes Thrombus Shell Expansion

2026-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Vessel-wall injury triggers platelet recruitment and aggregation with exquisite spatiotemporal regulation. While secreted agonists from thrombin-activated platelets play a crucial role in thrombus formation, the underlying mechanisms remain elusive. Using real-time imaging of isolated human platelets, we demonstrate that dense granules, which are enriched with agonists, are released in brief, st...

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Identifiers and source

Literature Corpus work: 933301a1-4654-5673-88f8-60f3f5607b08
DOI: 10.64898/2026.05.26.727941

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